Stability Indicating method for Estimation of Mefloquine Hydrochloride in Pharmaceutical Formulation

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ID: 309135
2025
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Ranked #31 of 153 articles by views in International Journal of Pharmaceutical Drug Design (IJPDD)

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Abstract
A simple, selective, rapid, precise and accurate reverse phase high pressure liquid chromatogram method has been developed and validate stability indicating RP-HPLC method for the estimation of Mefloqine hydrochloride in pharmaceutical formulations. Used developed and validate Hplc method for force degradation study. On the basis of reversed phase -HPLC mode (analyte) stationary phase with C18 bonded phase I.e waters symmetry c18 ,250 mm x 4.6 mm,5u was selected .Column with mobile phase consisting of 1.5 gm of sodium hydrogen sulphate mono hydrate(25) and 75 ml of methanol ,Detection was carried out at 280 nm and flow rate was 0.7 ml/Min .The developed method was validated for linearity accuracy, precision, selectivity, specificity, forced degradation studies, robustness ruggedness. By using the develop and validate RP- hplc method expedient study was carried out which is necessary in this case because the concentration of drug in the tablet formulation is very less than the other exciepients.
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Authors Smithhaa Mohod*, Pranjal Wankhede, VisheshMohod, Saurav Kumar
Journal International Journal of Pharmaceutical Drug Design (IJPDD)
Year 2025
DOI
10.62896/ijpdd.2.8.04
URL
https://ijpdd.org/index.php/files/article/view/314
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