Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

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ID: 307598
1987
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Abstract
ABSTRACT Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or α mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and α genes at the silent loci results from repression by trans-acting regulators encoded by SIR (Silent Information Regulator) genes. In this paper we present evidence for the existence of four SIRgenes. Inactivation of any of these genes leads to expression of cassettes at both HML and HMR. Unusual complementation properties are observed for a number of sir mutations. Specifically, some recessive mutations in different genes fail to complement. The correspondence between SIR1, SIR2, SIR3, SIR4 and other genes with similar roles (MAR, CMT, STE8 and STE9) is presented.
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openalex_W2114217399 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jasper Rine, Ira Herskowitz
Journal current genetics
Year 1987
DOI
10.1093/genetics/116.1.9
URL
https://academic.oup.com/genetics/article-pdf/116/1/9/34453016/genetics0009.pdf
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