Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function
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ID: 307499
1997
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Abstract
I. Introduction II. The Initial Identification of SF-1 as a Key Determinant of Steroid Hormone Biosynthesis A. Overview of steroidogenesis B. SF-1 and the regulation of steroidogenesis C. Cloning and structural characterization of SF-1 1. Structural features of SF-1 2. Multiple transcripts are encoded by the gene encoding SF-1 3. The gene encoding SF-1 is evolutionarily conserved in vertebrates and invertebrates III. Characterization of Sites of SF-1 Expression and Identification of Its Target Genes A. Profiles of SF-1 expression 1. Adult steroidogenic tissues 2. Embryonic steroidogenic tissues 3. Other sites of SF-1 expression B. Target genes regulated by SF-1 1. Steroidogenic cells 2. Sertoli cells 3. Gonadotropes 4. VMH IV. The Roles Of SF-1 in Vivo: Targeted Gene Disruption to Create SF-1 Knockout Mice A. General features of the SF-1 knockout mice B. Primary steroidogenic tissues in SF-1 knockout mice C. Pituitary and hypothalamic defects in SF-1 knockout mice V. Perspectives and Future Directions A. ...
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| Reference Key |
openalex_W2100859941
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|---|---|
| Authors | Keith L. Parker, Bernard P. Schimmer |
| Journal | endocrine reviews |
| Year | 1997 |
| DOI |
10.1210/edrv.18.3.0301
|
| URL | |
| Keywords | Keywords not found |
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