Skeletal Effects of Estrogen*

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ID: 307271
1994
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Abstract
BONE differs from reproductive tissues in that many aspects of skeletal growth, turnover, and function occur in the absence of gonadal hormones. Nevertheless, sex steroids have an important impact on bone physiology: they participate in the sexual dimorphism of the skeleton, play a role in maintenance of mineral homeostasis during reproduction, and are essential to maintaining bone balance in adults. Insufficient levels of certain sex steroids predispose the human skeleton to bone loss and to osteoporotic fractures. Estrogen appears to be the most important sex steroid in preventing osteoporosis in women and is the subject of this review. Serious difficulties must be overcome to understand the action of estrogen on mineralized tissues. The skeleton is heterogeneous and contains many cell types. The cells that synthesize (osteoblasts), lie within (osteocytes), and degrade (osteoclasts) bone matrix are present in small numbers, are difficult to isolate as pure populations, and probably do not proliferate.
Reference Key
openalex_W2012076119 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R. T. Turner, B. Lawrence Riggs, THOMAS C. SPELSBERG
Journal endocrine reviews
Year 1994
DOI
10.1210/edrv-15-3-275
URL
https://doi.org/10.1210/edrv-15-3-275
Keywords Keywords not found

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