Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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ID: 307120
2000
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Ranked #76 of 79 articles by views in Human molecular genetics

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Abstract
To understand gene expression changes mediated by a polyglutamine repeat expansion in the human huntingtin protein, we used oligonucleotide DNA arrays to profile ~6000 striatal mRNAs in the R6/2 mouse, a transgenic Huntington's disease (HD) model. We found diminished levels of mRNAs encoding components of the neurotransmitter, calcium and retinoid signaling pathways at both early and late symptomatic time points (6 and 12 weeks of age). We observed similar changes in gene expression in another HD mouse model (N171-82Q). These results demonstrate that mutant huntingtin directly or indirectly reduces the expression of a distinct set of genes involved in signaling pathways known to be critical to striatal neuron function.
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openalex_W2122440289 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ruth Luthi‐Carter
Journal Human molecular genetics
Year 2000
DOI
10.1093/hmg/9.9.1259
URL
https://doi.org/10.1093/hmg/9.9.1259
Keywords Keywords not found

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