Dendritic Anomalies in Disorders Associated with Mental Retardation

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ID: 306456
2000
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Ranked #65 of 107 articles by views in cerebral cortex (new york, ny : 1991)

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Abstract
Dendritic abnormalities are the most consistent anatomical correlates of mental retardation (MR). Earliest descriptions included dendritic spine dysgenesis, which was first associated with unclassified MR, but can also be found in genetic syndromes associated with MR. Genetic disorders with well-defined dendritic anomalies involving branches and/or spines include Down, Rett and fragile-X syndromes. Cytoarchitectonic analyses also suggest dendritic pathology in Williams and Rubinstein-Taybi syndromes. Dendritic abnormalities appear to have syndrome-specific pathogenesis and evolution, which correlate to some extent with their cognitive profile. The significance of dendritic pathology in synaptic circuitry and the role of animal models in the study of MR-associated dendritic abnormalities are also discussed. Finally, a model of genotype to neurologic phenotype pathway in MR, centered in dendritic abnormalities, is postulated.
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openalex_W2148386452 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Walter E. Kaufmann
Journal cerebral cortex (new york, ny : 1991)
Year 2000
DOI
10.1093/cercor/10.10.981
URL
https://academic.oup.com/cercor/article-pdf/10/10/981/9751007/100981.pdf
Keywords Keywords not found

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