Adipocytokines and the Metabolic Complications of Obesity

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ID: 306449
2008
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Abstract
Adipose tissue is increasingly recognized as an active endocrine organ with many secretory products and part of the innate immune system. With obesity, macrophages infiltrate adipose tissue, and numerous adipocytokines are released by both macrophages and adipocytes. Adipocytokines play important roles in the pathogenesis of insulin resistance and associated metabolic complications such as dyslipidemia, hypertension, and premature heart disease. Published literature was analyzed with the intent of addressing the role of the major adipose secretory proteins in human obesity, insulin resistance, and type 2 diabetes. This review analyzes the characteristics of different adipocytokines, including leptin, adiponectin, pro-inflammatory cytokines, resistin, retinol binding protein 4, visfatin, and others, and their roles in the pathogenesis of insulin resistance. Inflamed fat in obesity secretes an array of proteins implicated in the impairment of insulin signaling. Further studies are needed to understand the triggers that initiate inflammation in adipose tissue and the role of each adipokine in the pathogenesis of insulin resistance.
Reference Key
openalex_W2051415594 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Neda Rasouli, Philip A. Kern
Journal the journal of clinical endocrinology & metabolism
Year 2008
DOI
10.1210/jc.2008-1613
URL
https://doi.org/10.1210/jc.2008-1613
Keywords Keywords not found

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