Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

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ID: 306389
2007
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Abstract
This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDV
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Authors S. A. van Wolferen, J. Tim Marcus, A. Boonstra, Koen Marques, Jean G.F. Bronzwaer, Marieke D. Spreeuwenberg, Pieter E. Postmus, Anton Vonk Noordegraaf
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Journal european heart journal
Year 2007
DOI
10.1093/eurheartj/ehl477
URL
https://doi.org/10.1093/eurheartj/ehl477
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