Dopamine: A Prolactin-Inhibiting Hormone*

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ID: 306367
1985
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Abstract
DOPAMINE (DA) is an interesting and versatile compound. In the central nervous system (CNS) it is involved with the control of fine movements and mental processes. Its association with disorders such as Parkinsonism and schizophrenia is well recognized. In the hypothalamo-hypophysial axis, DA is the primary physiological inhibitor of PRL secretion. Currently, this catecholamine represents the only nonpeptidergic hypothalamic agent with a well defined hypophysiotropic function. By virtue of its dual role as a neurotransmitter and a hormone, DA provides perhaps the best example of neuroendocrine interactions. It also possesses a more universal property. In all hormonal systems studied thus far, whether at the hypothalamic, posterior pituitary, or anterior pituitary level, DA functions as an inhibitor. Perhaps the common denominator to these diverse cells is the presence of D2 DA receptors, which are negatively linked to the adenylate cyclase system.
Reference Key
openalex_W2104961787 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nira Ben‐Jonathan
Journal endocrine reviews
Year 1985
DOI
10.1210/edrv-6-4-564
URL
https://doi.org/10.1210/edrv-6-4-564
Keywords Keywords not found

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