Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily

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ID: 304854
2002
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Abstract
Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors, bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic factor, are synthesized as prepropeptide precursors and then processed and secreted as homodimers or heterodimers. Most ligands of the family signal through transmembrane serine/threonine kinase receptors and SMAD proteins to regulate cellular functions. Many studies have reported the characterization of knockout and knock-in transgenic mice as well as humans or other mammals with naturally occurring genetic mutations in superfamily members or their regulatory proteins. These investigations have revealed that TGF-β superfamily ligands, receptors, SMADs, and upstream and downstream regulators function in diverse developmental and physiological pathways. This review attempts to collate and integrate the extensive body of in vivo mammalian studies produced over the last decade.
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openalex_W2077243848 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hua Chang, Chester Brown, Martin M. Matzuk
Journal endocrine reviews
Year 2002
DOI
10.1210/er.2002-0003
URL
https://academic.oup.com/edrv/article-pdf/23/6/787/8860886/edrv0787.pdf
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