Neuroleptics and the Natural Course of Schizophrenia

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ID: 304768
1991
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Abstract
To determine if neuroleptic treatment changes the natural course of schizophrenia, 22 studies were reviewed in which relatively similar patients were or were not given neuroleptics at specific times during the course of their illnesses. Nineteen of the studies were from first- or predominately first-break populations. While there was little consensus among the authors of the studies reviewed, a reanalysis of the data indicates that early intervention with neuroleptics in first-break schizophrenic patients increases the likelihood of an improved long-term course. This finding is similar to that of earlier investigators who indicated there was a decrease in patients with the more severe forms of the illness following the introduction of convulsive therapies. Furthermore, there is evidence that stable schizophrenic patients whose neuroleptics are discontinued and have relapses may have a difficult time returning to their previous level of function. The findings described in this paper have implications for both the treatment of schizophrenia and for understanding the pathophysiological processes that determine the course of the disorder.
Reference Key
openalex_W2120012268 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors R J Wyatt
Journal schizophrenia bulletin
Year 1991
DOI
10.1093/schbul/17.2.325
URL
https://doi.org/10.1093/schbul/17.2.325
Keywords Keywords not found

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