Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

Clicks: 2
ID: 303765
2005
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Abstract
The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced glycation end products (AGEs), accumulate in a wide variety of environments. AGEs may be generated rapidly or over long times stimulated by a range of distinct triggering mechanisms, thereby accounting for their roles in multiple settings and disease states. A critical property of AGEs is their ability to activate receptor for advanced glycation end products (RAGE), a signal transduction receptor of the immunoglobulin superfamily. It is our hypothesis that due to such interaction, AGEs impart a potent impact in tissues, stimulating processes linked to inflammation and its consequences. We hypothesize that AGEs cause perturbation in a diverse group of diseases, such as diabetes, inflammation, neurodegeneration, and aging. Thus, we propose that targeting this pathway may represent a logical step in the prevention/treatment of the sequelae of these disorders.
Reference Key
openalex_W2142060886 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ravichandran Ramasamy, Susan J. Vannucci, Shirley Shi Du Yan, Kevan C. Herold, Shi Fang Yan, Ann Marie Schmidt
Journal glycobiology
Year 2005
DOI
10.1093/glycob/cwi053
URL
https://academic.oup.com/glycob/article-pdf/15/7/16R/2024096/cwi053.pdf
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