Macrophage activation switching: an asset for the resolution of inflammation

Clicks: 17
ID: 303381
2005
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Abstract
Summary Macrophages play a central role in inflammation and host defence against microorganisms, but they also participate actively in the resolution of inflammation after alternative activation. However, it is not known whether the resolution of inflammation requires alternative activation of new resting monocytes/macrophages or if proinflammatory activated macrophages have the capacity to switch their activation towards anti-inflammation. In order to answer this question, we first characterized differential human macrophage activation phenotypes. We found that CD163 and CD206 exhibited mutually exclusive induction patterns after stimulation by a panel of anti-inflammatory molecules, whereas CCL18 showed a third, overlapping, pattern. Hence, alternative activation is not a single process, but provides a variety of different cell populations. The capacity of macrophages to switch from one activation state to another was then assessed by determining the reversibility of CD163 and CD206 expression and of CCL18 and CCL3 production. We found that every activation state was rapidly and fully reversible, suggesting that a given cell may participate sequentially in both the induction and the resolution of inflammation. These findings may provide new insight into the inflammatory process as well as new fields of investigation for immunotherapy in the fields of chronic inflammatory diseases and cancer.
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openalex_W1983220630 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fabrice Porcheray, Sophie Viaud, A.C. Rimaniol, Cathie Léone, Boubekeur Samah, Nathalie Dereuddre‐Bosquet, D Dormont, Gabriel Gras
Journal Clinical & Experimental Immunology
Year 2005
DOI
10.1111/j.1365-2249.2005.02934.x
URL
https://doi.org/10.1111/j.1365-2249.2005.02934.x
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