A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223
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ID: 303072
2016
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Abstract
Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling represents an early event in the clinical course leading to heart failure. Maladaptive hypertrophy is considered to be a therapeutic target for heart failure. However, the molecular mechanisms that regulate cardiac hypertrophy are largely unknown.Here we show that a circular RNA (circRNA), which we term heart-related circRNA (HRCR), acts as an endogenous miR-223 sponge to inhibit cardiac hypertrophy and heart failure. miR-223 transgenic mice developed cardiac hypertrophy and heart failure, whereas miR-223-deficient mice were protected from hypertrophic stimuli, indicating that miR-223 acts as a positive regulator of cardiac hypertrophy. We identified ARC as a miR-223 downstream target to mediate the function of miR-223 in cardiac hypertrophy. Apoptosis repressor with CARD domain transgenic mice showed reduced hypertrophic responses. Further, we found that a circRNA HRCR functions as an endogenous miR-223 sponge to sequester and inhibit miR-223 activity, which resulted in the increase of ARC expression. Heart-related circRNA directly bound to miR-223 in cytoplasm and enforced expression of HRCR in cardiomyocytes and in mice both exhibited attenuated hypertrophic responses.These findings disclose a novel regulatory pathway that is composed of HRCR, miR-223, and ARC. Modulation of their levels provides an attractive therapeutic target for the treatment of cardiac hypertrophy and heart failure.
| Reference Key |
openalex_W2346480860
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|---|---|
| Authors | Kun Wang, Bo Long, Fang Liu, Jianxun Wang, Cui-Yun Liu, Bing Zhao, Lu‐Yu Zhou, Teng Sun, Man Wang, Tao Yu, Ying Gong, Jia Liu, Yanhan Dong, Na Li, Peifeng Li |
| Journal | european heart journal |
| Year | 2016 |
| DOI |
10.1093/eurheartj/ehv713
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| URL | |
| Keywords | Keywords not found |
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