The Two-syndrome Concept: Origins and Current Status

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ID: 302686
1985
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Abstract
The two-syndrome concept postulates two "dimensions of pathology" underlying schizophrenia--a reversible (and potentially neuroleptic-responsive) component and a sometimes progressive and relatively irreversible component associated with the deficit state and poor long-term outcome. Negative symptoms (narrowly defined) appear to be more closely associated with the latter component (the type II syndrome), as also are cognitive impairments, abnormal involuntary movements, and behavioral deterioration. This syndrome is assumed to be more closely related than the type I syndrome of positive symptoms to the structural brain changes inferred from pneumoencephalograms, computed tomography scans, and recent post-mortem studies. However, since both syndromes often occur in the same patient--sometimes at the same point in time--they presumably have the same etiology.
Reference Key
openalex_W2061560549 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Timothy J. Crow
Journal schizophrenia bulletin
Year 1985
DOI
10.1093/schbul/11.3.471
URL
https://doi.org/10.1093/schbul/11.3.471
Keywords Keywords not found

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