Requirement of Interleukin‐17A for Systemic Anti–Candida albicansHost Defense in Mice

Clicks: 4
ID: 302493
2004
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #285 of 432 articles by views in The Journal of infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 432 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
T cells are required for normal host defense against fungal infection, and individuals with T cell.deficiency syndromes are highly susceptible to fungal pathogens. Interleukin (IL)-17A is a proinflammatory cytokine that interconnects myeloid and lymphoid host defense. The role of murine (m) IL-17A/mIL-17A receptor (R) interactions was evaluated in a murine model of systemic candidiasis. In response to systemic challenge with Candida albicans, expression of mIL-17A was induced, and IL-17AR knockout (IL-17AR−/−) mice had dosedependent, substantially reduced survival. Fungal burden in the kidneys of IL-17AR−/− mice was dramatically increased (25-fold at 96 h). In IL-17AR−/− mice, both mobilization of peripheral neutrophils and their influx to infected organs were significantly impaired and delayed. In vivo expression of mIL-17A protected normal mice from a lethal dose of C. albicans (100% at day 7 and 65% at day 42). The data suggest that the mIL- 17A/mIL-17AR system is required for normal fungal host defense in vivo. IL-17A could have potential as a therapeutic cytokine for systemic C. albicans infections in immunocompromised patients with cancer or advanced acquired immunodeficiency syndrome.
Reference Key
openalex_W2112133235 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Weitao Huang, Li Na, Paul L. Fidel, Paul Schwarzenberger
Journal The Journal of infectious diseases
Year 2004
DOI
10.1086/422329
URL
https://doi.org/10.1086/422329
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.