The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion

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ID: 302118
1994
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Abstract
Abstract The accumulation of leukocytes in inflamed tissue results from adhesive interactions between leukocytes and endothelial cells within the microcirculation. These adhesive interactions and the excessive filtration of fluid and protein that accompanies an inflammatory response are largely confined to one region of the microvasculature: postcapillary venules. The nature and magnitude of the leukocyte–endothelial cell adhesive interactions that take place within postcapillary venules are determined by a variety of factors, including expression of adhesion molecules on leukocytes and/or endothelial cells, products of leukocyte (superoxide) and endothelial cell (nitric oxide) activation, and the physical forces generated by the movement of blood along the vessel wall. The contribution of different adhesion molecules to leukocyte rolling, adherence, and emigration in venules is discussed. Emerging views on potential endogenous antiadhesion molecules produced by endothelial cells as well as the influence of alterations in shear rate on leukocyte adhesion are addressed. Finally, the pathophysiological significance of the microvascular responses to inflammation are discussed in terms of adhesion-directed strategies for the treatment of different cardiovascular diseases and circulatory disorders. J. Leukoc. Biol. 55: 662–675; 1994.
Reference Key
openalex_W2132925738 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors D. Neil Granger, Paul Kubes
Journal journal of leukocyte biology
Year 1994
DOI
10.1002/jlb.55.5.662
URL
https://doi.org/10.1002/jlb.55.5.662
Keywords Keywords not found

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