Dissociable Functions in the Medial and Lateral Orbitofrontal Cortex: Evidence from Human Neuroimaging Studies

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ID: 301028
2000
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Abstract
Recent imaging studies show that the orbitofrontal cortex (OFC) is activated during a wide variety of paradigms, including guessing tasks, simple delayed matching tasks and sentence completion. We suggest that, as with other regions of the prefrontal cortex, activity in the OFC is most likely to be observed when there is insufficient information available to determine the appropriate course of action. In these circumstances the OFC, rather than other prefrontal regions, is more likely to be activated when the problem of what to do next is best solved by taking into account the likely reward value of stimuli and responses, rather than their identity or location. We suggest that selection of stimuli on the basis of their familiarity and responses on the basis of a feeling of ‘rightness' are also examples of selection on the basis of reward value. Within the OFC, the lateral regions are more likely to be involved when the action selected requires the suppression of previously rewarded responses.
Reference Key
openalex_W2156777444 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rebecca Elliott, Raymond J. Dolan, Chris Frith
Journal cerebral cortex (new york, ny : 1991)
Year 2000
DOI
10.1093/cercor/10.3.308
URL
https://doi.org/10.1093/cercor/10.3.308
Keywords Keywords not found

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