What Makes Clinical Research in Developing Countries Ethical? The Benchmarks of Ethical Research

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ID: 300670
2004
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Abstract
In recent years there has been substantial debate about the ethics of research in developing countries. In general the controversies have centered on 3 issues: first the standard of care that should be used in research in developing countries; second the “reasonable availability” of interventions that are proven to be useful during the course of research trials; and third the quality of informed consent. The persistence of controversies on such issues reflects in part the fact that existing ethical guidelines can be interpreted in multiple ways are sometimes contradictory or rely on unstated yet controversial ethical principles. To provide unified and consistent ethical guidance we apply a previously proposed ethical framework for clinical research within developed countries to developing countries explicating a previously implicit requirement for collaboration. More importantly we propose specific and practical benchmarks to guide researchers and research-ethics committees in assessing how well the enumerated ethical principles have been fulfilled in particular cases. (excerpt)
Reference Key
openalex_W2165845288 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ezekiel J. Emanuel, David Wendler, Jack Killen, Christine Grady
Journal The Journal of infectious diseases
Year 2004
DOI
10.1086/381709
URL
https://academic.oup.com/jid/article-pdf/189/5/930/6024850/189-5-930.pdf
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