Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease*
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ID: 300562
1980
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Abstract
We evaluated basal plasma total immunoreactive insulin (insulin), androstenedione, and testosterone in 14 obesewomen: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P < 0.02 to P < 0.001) in PCOD patients. A significant correlation amon basal levels of plasma insulin, androstenedione, and testosterone was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2, and 3 h, with similar significant increases in plasma insulin levels at 0, 2, and 3 h. A significant correlation was found between plasma insulin response areas and plasma testosterone (P < 0.001) in the control and PCOD patients. These studies demonstrate that hyperandrogenism correlates with hyperinsulinism.
| Reference Key |
openalex_W2138910558
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|---|---|
| Authors | George A. Burghen, James R. Givens, Abbas E. Kitabchi |
| Journal | the journal of clinical endocrinology & metabolism |
| Year | 1980 |
| DOI |
10.1210/jcem-50-1-113
|
| URL | |
| Keywords | Keywords not found |
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