Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

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ID: 300238
1986
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Abstract
8-Hydroxydeoxyguanosine (8-OH-dG) was detected in DNA isolated from HeLa cells after the cells in tissue culture had been irradiated with X-rays and from the liver of mice after the whole animals had been irradiated with γ-rays. The amounts of 8-OH-dG in DNA after in vivo irradiation were three orders of magnitude lower than those after in vitro irradiation (0.008–0.032 8-OH-dG residue/105 dG/krad). The 8-OH-dG produced in liver DNA by irradiation of mice decreased with time, suggesting the presence of a repair en-zyme(s) acting on 8-OH-dG in mouse liver. Treatment of Salmonella typhimurium cells with hydrogen peroxide also caused increase in the 8-OH-dG content. These results indicate that 8-OH-dG is formed in vivo in cellular DNA on treatment with various oxygen radical-producing agents and that it is repairable.
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openalex_W1980742722 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hiroshi Kasai, P. F. Crain, Yoshiyuki Kuchino, Susumu Nishimura, Akira Ootsuyama, Hiroshi Tanooka
Journal journal of carcinogenesis
Year 1986
DOI
10.1093/carcin/7.11.1849
URL
https://doi.org/10.1093/carcin/7.11.1849
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