Simple methods for testing the molecular evolutionary clock hypothesis.

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ID: 299817
1993
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Abstract
Abstract Simple statistical methods for testing the molecular evolutionary clock hypothesis are developed which can be applied to both nucleotide and amino acid sequences. These methods are based on the chi-square test and are applicable even when the pattern of substitution rates is unknown and/or the substitution rate varies among different sites. Furthermore, some of the methods can be applied even when the outgroup is unknown. Using computer simulations, these methods were compared with the likelihood ratio test and the relative rate test. The results indicate that the powers of the present methods are similar to those of the likelihood ratio test and the relative rate test, in spite of the fact that the latter two tests assume that the pattern of substitution rates follows a certain model and that the substitution rate is the same among different sites, while such assumptions are not necessary to apply the present methods. Therefore, the present methods might be useful.
Reference Key
openalex_W2133104753 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fumio Tajima
Journal current genetics
Year 1993
DOI
10.1093/genetics/135.2.599
URL
https://academic.oup.com/genetics/article-pdf/135/2/599/34593395/genetics0599.pdf
Keywords Keywords not found

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