Brain Volumes in Schizophrenia: A Meta-Analysis in Over 18 000 Subjects

Clicks: 47
ID: 299785
2012
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #10 of 54 articles by views in schizophrenia bulletin

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Although structural brain alterations in schizophrenia have been demonstrated extensively, their quantitative distribution has not been studied over the last 14 years despite advances in neuroimaging. Moreover, a volumetric meta-analysis has not been conducted in antipsychotic-naive patients. Therefore, meta-analysis on cross-sectional volumetric brain alterations in both medicated and antipsychotic-naive patients was conducted. Three hundred seventeen studies published from September 1, 1998 to January 1, 2012 comprising over 9000 patients were selected for meta-analysis, including 33 studies in antipsychotic-naive patients. In addition to effect sizes, potential modifying factors such as duration of illness, sex composition, current antipsychotic dose, and intelligence quotient matching status of participants were extracted where available. In the sample of medicated schizophrenia patients (n = 8327), intracranial and total brain volume was significantly decreased by 2.0% (effect size d = −0.17) and 2.6% (d = −0.30), respectively. Largest effect sizes were observed for gray matter structures, with effect sizes ranging from −0.22 to −0.58. In the sample of antipsychotic-naive patients (n = 771), volume reductions in caudate nucleus (d = −0.38) and thalamus (d = −0.68) were more pronounced than in medicated patients. White matter volume was decreased to a similar extent in both groups, while gray matter loss was less extensive in antipsychotic-naive patients. Gray matter reduction was associated with longer duration of illness and higher dose of antipsychotic medication at time of scanning. Therefore, brain loss in schizophrenia is related to a combination of (early) neurodevelopmental processes—reflected in intracranial volume reduction—as well as illness progression.
Reference Key
openalex_W2162950935 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sander V. Haijma, Neeltje E.M. van Haren, Wiepke Cahn, P. Cédric M. P. Koolschijn, Hilleke E. Hulshoff Pol, René S. Kahn
Journal schizophrenia bulletin
Year 2012
DOI
10.1093/schbul/sbs118
URL
https://doi.org/10.1093/schbul/sbs118
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.