Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

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ID: 299774
1995
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Abstract
SUMMARY Hyporesponsiveness to a universe of bacterial and dietary antigens from the gut lumen is a hallmark of the intestinal immune system. Since hyperresponsiveness against these antigens might be associated with inflammation, we studied the immune response to the indigenous intestinal microflora in peripheral blood, inflamed and non-inflamed human intestine. Lamina propria monocuclear cells (LPMC) isolated from inflamed intestine but not peripheral blood mononuclear cells (PBMC) of IBD patients with active inflammatory disease strongly proliferated after co-culture with sonicates of bacteria from autologous intestine (BsA), Proliferation was inhibitable by anti-MHC class II MoAb, suggesting that it was driven by antigen, LPMC from adjacent non-inflamed intestinal areas of the same IBD patients and PBMC or LPMC isolated from non-inflamed intestine of controls and patients with IBD in remission, in contrast, did not proliferate, PBMC or LPMC which had been tolerant to bacteria from autologous intestine, however, strongly proliferated after co-culture with bacterial sonicates from heterologous intestine (BsH). This proliferation was associated with an expansion of CD8+ T cells, increased expression of activation markers on both CD4+ and CD8+ lymphocyte subsets, and production of IL-12, interferon-gamma (IFN-γ), and IL-10 protein. These results show that tolerance selectively exists to intestinal flora from autologous but not heterologous intestine, and that tolerance is broken in intestinal inflammation. This may be an important mechanism for the perpetuation of chronic IBD.
Reference Key
openalex_W2090631845 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rainer Duchmann, I Kaiser, E Hermann, W.-J. Mayet, Klaus Ewe, K-H MEYER ZUM BÜSCHENFELDE
Journal Clinical & Experimental Immunology
Year 1995
DOI
10.1111/j.1365-2249.1995.tb03836.x
URL
https://doi.org/10.1111/j.1365-2249.1995.tb03836.x
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