An evaluation of genetic distances for use with microsatellite loci.

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ID: 299349
1995
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Abstract
Abstract Mutations of alleles at microsatellite loci tend to result in alleles with repeat scores similar to those of the alleles from which they were derived. Therefore the difference in repeat score between alleles carries information about the amount of time that has passed since they shared a common ancestral allele. This information is ignored by genetic distances based on the infinite alleles model. Here we develop a genetic distance based on the stepwise mutation model that includes allelic repeat score. We adapt earlier treatments of the stepwise mutation model to show analytically that the expectation of this distance is a linear function of time. We then use computer simulations to evaluate the overall reliability of this distance and to compare it with allele sharing and Nei's distance. We find that no distance is uniformly superior for all purposes, but that for phylogenetic reconstruction of taxa that are sufficiently diverged, our new distance is preferable.
Reference Key
openalex_W1907733689 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors David B. Goldstein, Andrés Ruiz‐Linares, L. L. Cavalli‐Sforza, M.W. Feldman
Journal current genetics
Year 1995
DOI
10.1093/genetics/139.1.463
URL
https://academic.oup.com/genetics/article-pdf/139/1/463/34604848/genetics0463.pdf
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