Innate Immunity Cells and the Neurovascular Unit

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ID: 29932
2018
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Abstract
Recent studies have clarified many still unknown aspects related to innate immunity and the blood-brain barrier relationship. They have also confirmed the close links between effector immune system cells, such as granulocytes, macrophages, microglia, natural killer cells and mast cells, and barrier functionality. The latter, in turn, is able to influence not only the entry of the cells of the immune system into the nervous tissue, but also their own activation. Interestingly, these two components and their interactions play a role of great importance not only in infectious diseases, but in almost all the pathologies of the central nervous system. In this paper, we review the main aspects in the field of vascular diseases (cerebral ischemia), of primitive and secondary neoplasms of Central Nervous System CNS, of CNS infectious diseases, of most common neurodegenerative diseases, in epilepsy and in demyelinating diseases (multiple sclerosis). Neuroinflammation phenomena are constantly present in all diseases; in every different pathological state, a variety of innate immunity cells responds to specific stimuli, differentiating their action, which can influence the blood-brain barrier permeability. This, in turn, undergoes anatomical and functional modifications, allowing the stabilization or the progression of the pathological processes.
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presta2018innateinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Presta, Ivan;Vismara, Marco Flavio Michele;Novellino, Fabiana;Donato, Annalidia;Zaffino, Paolo;Scali, Elisabetta;Pirrone, Krizia Caterina;Spadea, Maria Francesca;Malara, Natalia;Donato, Giuseppe;
Journal International journal of molecular sciences
Year 2018
DOI
DOI not found
URL
https://www.mdpi.com/1422-0067/19/12/3856
Keywords Keywords not found

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