One-Sample Multiple Testing Procedure for Phase II Clinical Trials

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ID: 299081
1982
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Abstract
Commonly, the central objective of Phase II clinical trials is the assessment of the antitumor 'therapeutic efficacy' of a specific treatment regimen. It is of interest to formulate test procedures which can be employed in these trials to decide whether or not this therapeutic efficacy warrants further investigation. For ethical reasons, these procedures should allow for early termination if initial results are extreme. In this paper, a one-sample multiple testing procedure is proposed which employs the standard single-stage test procedure at the last test, and which both allows for early termination and essentially preserves the size, power and simplicity of the single-stage procedure.
Reference Key
openalex_W1984254136 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thomas R. Fleming
Journal biometrics
Year 1982
DOI
10.2307/2530297
URL
https://doi.org/10.2307/2530297
Keywords Keywords not found

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