Regulation of the Acute Production of Steroids in Steroidogenic Cells*

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ID: 299066
1996
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Abstract
The mechanism regulating the production of steroids in response to trophic hormone stimulation has been the subject of investigation for over three decades. When considering the effects of trophic hormones on the steroidogenic process it is necessary to first distinguish between acute effects and chronic effects. Acute effects are those which result in the very rapid (within minutes) synthesis and secretion of steroids in response to hormone stimulation and involve the rapid translocation of intracellular cholesterol to the site of its cleavage, as will be discussed later. Chronic effects are those which occur on the order of hours to tens of hours and involve increased gene transcription and translation of the proteins involved in the biosynthesis of steroids. This chapter will focus on studies designed to elucidate the mechanisms involved in the acute regulation of steroid production in response to hormone stimulation. Overviews of the effects of chronic stimulation on steroidogenic enzymes have appeared in several excellent review articles (Simpson and Waterman 1983; Miller 1988; Hanukoglu 1992).
Reference Key
openalex_W2165101701 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Douglas M. Stocco, Barbara J. Clark
Journal endocrine reviews
Year 1996
DOI
10.1210/edrv-17-3-221
URL
https://doi.org/10.1210/edrv-17-3-221
Keywords Keywords not found

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