The CD14+ CD16+ blood monocytes: their role in infection and inflammation

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ID: 299040
2006
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Abstract
Abstract Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16− and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of publications about CD14+ CD16+ monocytes in inflammation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease.
Reference Key
openalex_W1991026693 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Loems Ziegler‐Heitbrock
Journal journal of leukocyte biology
Year 2006
DOI
10.1189/jlb.0806510
URL
https://doi.org/10.1189/jlb.0806510
Keywords Keywords not found

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