Essential involvement of interleukin-8 (IL-8) in acute inflammation

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ID: 298956
1994
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Abstract
Abstract Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. Locally produced chemotactic factors are presumed to mediate the sequence of events leading to the infiltration at inflammatory sites. Interleukin-8 (IL-8), a novel leukocyte chemotactic activating cytokine (chemokine), is produced by various types of cells upon stimulation with inflammatory stimuli and exerts a variety of functions on leukocytes, particularly, neutrophils in vitro. However, no definitive evidence has been presented on its role in recruiting and activating neutrophils in the lesions of various types of inflammatory reactions. We administered a highly specific neutralizing antibody against IL-8 in several types of acute inflammatory reactions, including lipopolysaccharide (LPS)-induced dermatitis, LPS/IL-1-induced arthritis, lung reperfusion injury, and acute immune complex-type glomerulonephritis. Anti-IL-8 treatment prevented neutrophil-dependent tissue damage as well as neutrophil infiltration in these conditions. These results suggest that IL-8 plays a causative role in acute inflammation by recruiting and activating neutrophils. J. Leukoc. Biol. 56: 559–564; 1994.
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Authors Akihisa Harada, Nobuaki Sekido, Tohru Akahoshi, Takashi Wada, Naofumi Mukaida, Kouji Matsushima
Journal journal of leukocyte biology
Year 1994
DOI
10.1002/jlb.56.5.559
URL
https://doi.org/10.1002/jlb.56.5.559
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