Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method

Clicks: 26
ID: 298172
1997
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Abstract
A new, simple method for predicting transmembrane segments in integral membrane proteins has been developed. It is based on low-stringency dot-plots of the query sequence against a collection of non-homologous membrane proteins using a previously derived scoring matrix [Cserzö et al., 1994, J. Mol. Biol., 243, 388-396]. This so-called dense alignment surface (DAS) method is shown to perform on par with earlier methods that require extra information in the form of multiple sequence alignments or the distribution of positively charged residues outside the transmembrane segments, and thus improves prediction abilities when only single-sequence information is available or for classes of membrane proteins that do not follow the 'positive inside' rule.
Reference Key
openalex_W2115840790 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Miklós Cserző, Erik Jakob Wallin, István Simon, Gunnar von Heijne, Arne Elofsson
Journal Protein Engineering Design and Selection
Year 1997
DOI
10.1093/protein/10.6.673
URL
https://doi.org/10.1093/protein/10.6.673
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