Multiple control of interleukin-8 gene expression

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ID: 298146
2002
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Abstract
Abstract Interleukin (IL)-8, a prototypic human chemokine, was detected more than a decade ago as the founding member of the chemokine superfamily. One of the most remarkable properties of IL-8 is the variation of its expression levels. In healthy tissues, IL-8 is barely detectable, but it is rapidly induced by ten- to 100-fold in response to proinflammatory cytokines such as tumor necrosis factor or IL-1, bacterial or viral products, and cellular stress. Recently, significant advances in the understanding of signaling pathways, which coordinately regulate IL-8 transcription as well as mRNA stabilization in response to external stimuli, have been made. Maximal IL-8 amounts are generated by a combination of three different mechanisms: first, derepression of the gene promoter; second, transcriptional activation of the gene by nuclear factor-κB and JUN-N-terminal protein kinase pathways; and third, stabilization of the mRNA by the p38 mitogen-activated protein kinase pathway. In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury.
Reference Key
openalex_W2149122802 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Elke Hoffmann, Oliver Dittrich‐Breiholz, Helmut Holtmann, Michael Kracht
Journal journal of leukocyte biology
Year 2002
DOI
10.1189/jlb.72.5.847
URL
https://doi.org/10.1189/jlb.72.5.847
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