Soft Sweeps

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ID: 297787
2005
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Abstract
A population can adapt to a rapid environmental change or habitat expansion in two ways. It may adapt either through new beneficial mutations that subsequently sweep through the population or by using alleles from the standing genetic variation. We use diffusion theory to calculate the probabilities for selective adaptations and find a large increase in the fixation probability for weak substitutions, if alleles originate from the standing genetic variation. We then determine the parameter regions where each scenario-standing variation vs. new mutations-is more likely. Adaptations from the standing genetic variation are favored if either the selective advantage is weak or the selection coefficient and the mutation rate are both high. Finally, we analyze the probability of "soft sweeps," where multiple copies of the selected allele contribute to a substitution, and discuss the consequences for the footprint of selection on linked neutral variation. We find that soft sweeps with weaker selective footprints are likely under both scenarios if the mutation rate and/or the selection coefficient is high.
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openalex_W2118055782 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Joachim Hermisson, Pleuni S. Pennings
Journal current genetics
Year 2005
DOI
10.1534/genetics.104.036947
URL
https://academic.oup.com/genetics/article-pdf/169/4/2335/42067308/genetics2335.pdf
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