Mitochondrial portraits of human populations using median networks.

Clicks: 2
ID: 297398
1995
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Abstract
Abstract Analysis of variation in the hypervariable region of mitochondrial DNA (mtDNA) has emerged as an important tool for studying human evolution and migration. However, attempts to reconstruct optimal intraspecific mtDNA phylogenies frequently fail because parallel mutation events partly obscure the true evolutionary pathways. This makes it inadvisable to present a single phylogenetic tree at the expense of neglecting equally acceptable ones. As an alternative, we propose a novel network approach for portraying mtDNA relationships. For small sample sizes (< approximately 50), an unmodified median network contains all most parsimonious trees, displays graphically the full information content of the sequence data, and can easily be generated by hand. For larger sample sizes, we reduce the complexity of the network by identifying parallelisms. This reduction procedure is guided by a compatibility argument and an additional source of phylogenetic information: the frequencies of the mitochondrial haplotypes. As a spin-off, our approach can also assist in identifying sequencing errors, which manifest themselves in implausible network substructures. We illustrate the advantages of our approach with several examples from existing data sets.
Reference Key
openalex_W1834060250 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors H. -J. Bandelt, Peter Forster, B C Sykes, Martin Richards
Journal current genetics
Year 1995
DOI
10.1093/genetics/141.2.743
URL
https://doi.org/10.1093/genetics/141.2.743
Keywords Keywords not found

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