Evaluation of the fusion inhibitor P3 peptide as a potential microbicide to prevent HIV transmission in women.

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ID: 29702
2018
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Abstract
Microbicides are an important strategy for preventing the sexual transmission of HIV but, so far, the most advanced tenofovir-based microbicides have had modest efficacy. This has been related to adherence problems and high prevalence of tenofovir-resistant HIV-1 strains. P3 is a new peptide with potent activity against HIV that may be a good microbicide candidate. In this work P3 was formulated in a gel of hydroxyethyl cellulose and its activity, stability and safety profile in Balb/c mice were evaluated. HIV infection was fully blocked by a 1.5% gel containing P3 at the IC90 (366.4 nM) concentration. The antiviral activity did not change at 4°C during 4 months and at 25, 37 and 65°C for 1 week. P3 was stable and fully functional at acidic pH up to 24h, under different concentrations of hydrogen peroxide and in the presence of genital fluids up to 48h. P3 had no antibacterial activity and did not affect sperm motility and vitality. Finally, P3 didn't cause significant alterations in the vaginal epithelium of Balb/c mice at 0.06 (456.8 μM) and 0.2 mg/day (1522.7 μM) doses. These findings indicate that P3 is an excellent candidate for further development as a microbicide gel for the prevention of HIV transmission in women.
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brtolo2018evaluationplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bártolo, Inês;Diniz, Ana Rita;Borrego, Pedro;Ferreira, João Pedro;Bronze, Maria Rosário;Barroso, Helena;Pinto, Rui;Cardoso, Carlos;Pinto, João F;Diaz, Rafael Ceña;Broncano, Pilar Garcia;Muñoz-Fernández, Maria Angel;Taveira, Nuno;
Journal PloS one
Year 2018
DOI
10.1371/journal.pone.0195744
URL
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