Design, synthesis and evaluation of halogenated furanone derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa.

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ID: 29690
2019
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Ranked #4 of 60 articles by views in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

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Abstract
The biofilm formation of Pseudomonas aeruginosa (P. aeruginosa) is regulated by a phenomenon of quorum sensing (QS). With 5-hydroxyl-3,4-halogenated-5H-furan-2-ones as beginning, analogs bearing alkyl chains, vinyl bromide, or aromatic rings were designed and synthesized. The minimum inhibitory concentration (MIC) of the compounds against P. aeruginosa was assayed and the biofilm inhibition ratio was determined at different concentrations lower than the MIC. C-5 aromatic substituted furanones showed remarkable biofilm formation as well as inhibition of virulence factor production in P. aeruginosa. Fluorescence report analysis identified the QS regulatory mechanism of the most active compound 29. This study provides us a novel candidate for combating drug resistant bacteria strains by merely inhibiting biofilm formation. Without suppressing the regular life cycle of the bacteria, bacterial resistance mechanisms may not be activated.
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chang2019designeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chang, Yiqun;Wang, Peng-Cheng;Ma, Hong-Ming;Chen, Si-Yu;Fu, Yu-Hang;Liu, Yuan-Yuan;Wang, Xuan;Yu, Guang-Chao;Huang, Tao;Hibbs, David E;Zhou, Hai-Bo;Chen, Wei-Min;Lin, Jing;Wang, Chao;Zheng, Jun-Xia;Sun, Ping-Hua;
Journal European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Year 2019
DOI
S0928-0987(19)30329-X
URL
Keywords Keywords not found

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