"Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?
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ID: 296466
1998
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Abstract
Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been replaced by models that postulate a disruption in parallel distributed or dynamic circuits. Based on empirical data derived from both magnetic resonance and positron emission tomography, we have developed a model that implicates connectivity among nodes located in prefrontal regions, the thalamic nuclei, and the cerebellum. A disruption in this circuitry produces “cognitive dysmetria,” difficulty in prioritizing, processing, coordinating, and responding to information. This “poor mental coordination” is a fundamental cognitive deficit in schizophrenia and can account for its broad diversity of symptoms.
| Reference Key |
openalex_W2126159475
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|---|---|
| Authors | Nancy C. Andreasen, Sergio Paradiso, Daniel S. OʼLeary |
| Journal | schizophrenia bulletin |
| Year | 1998 |
| DOI |
10.1093/oxfordjournals.schbul.a033321
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| URL | |
| Keywords | Keywords not found |
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