Quantifying Publication Bias in Meta-Analysis

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ID: 295402
2017
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Abstract
Publication bias is a serious problem in systematic reviews and meta-analyses, which can affect the validity and generalization of conclusions. Currently, approaches to dealing with publication bias can be distinguished into two classes: selection models and funnel-plot-based methods. Selection models use weight functions to adjust the overall effect size estimate and are usually employed as sensitivity analyses to assess the potential impact of publication bias. Funnel-plot-based methods include visual examination of a funnel plot, regression and rank tests, and the nonparametric trim and fill method. Although these approaches have been widely used in applications, measures for quantifying publication bias are seldom studied in the literature. Such measures can be used as a characteristic of a meta-analysis; also, they permit comparisons of publication biases between different meta-analyses. Egger's regression intercept may be considered as a candidate measure, but it lacks an intuitive interpretation. This article introduces a new measure, the skewness of the standardized deviates, to quantify publication bias. This measure describes the asymmetry of the collected studies' distribution. In addition, a new test for publication bias is derived based on the skewness. Large sample properties of the new measure are studied, and its performance is illustrated using simulations and three case studies.
Reference Key
openalex_W2769488285 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lifeng Lin, Haitao Chu
Journal biometrics
Year 2017
DOI
10.1111/biom.12817
URL
https://doi.org/10.1111/biom.12817
Keywords Keywords not found

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