Derivatization of Natural Compound β-Pinene Enhances Its In Vitro Antifungal Activity against Plant Pathogens.

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ID: 29511
2019
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Abstract
The development of new antifungal agents has always been a hot research topic in pesticide development. In this study, a series of derivatives of natural compound β-pinene were prepared, and the antifungal activities of these derivatives were evaluated. The purpose of this work is to develop some novel molecules as promising new fungicides.Through a variety of chemical reactions, β-pinene was transformed into a series of β-pinene-based derivatives containing amide moieties and acylthiourea moieties. The antifungal activities of these derivatives against five plant pathogens including , , , sp. and were tested; preliminary structure-activity relationship was discussed.Some derivatives exhibited moderate or significant antifungal activity due to the fusion of the amide moiety or the acylthiourea moiety with the pinane skeleton. The structure-activity relationship analysis showed that the fluorine atom and the strong electron withdrawing nitro group, or trifluoromethyl group on the benzene ring of the derivatives had a significant effect on the improvement of the antifungal activity against , , and sp. Meanwhile, the introduction of an ethyl group at the meta-position on the benzene ring of the derivatives could improve the antifungal activity against . Compounds , , , exhibited broad-spectrum antifungal activity against the tested strains. Compound had significant antifungal activity against (IC = 0.18 μmol/L). These derivatives were expected to be used as precursor molecules for novel pesticide development in further research.
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shi2019derivatizationmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shi, Yunfei;Si, Hongyan;Wang, Peng;Chen, Shangxing;Shang, Shibin;Song, Zhanqian;Wang, Zongde;Liao, Shengliang;
Journal molecules
Year 2019
DOI
E3144
URL
Keywords Keywords not found

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