ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES

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ID: 295030
1976
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Abstract
The concepts that case-referent studies provide for the estimation of "relative risk" only if the illness is "rare," and that the rates and risks themselves are inestimable, are overly superficial and restrictive. The ratio of incidence densities (forces of morbidity)—and thereby the instantaneous risk-ratio—is estimable without any rarity-assumption. Long-term risk-ratio can be computed through the coupling of case-referent data on exposure rates for various age-categories with estimates, possibly from the study itself, of the corresponding age-specific incidence-densities for the exposed and nonexposed combined—but again, no rarity-assumption is involved. Such data also provide for the assessment of exposure-specific absolute incidence-rates and risks. Point estimation of the various parameters can be based on simple relationships among them, and in interval estimation it is sufficient simply to couple the point estimate with the value of the chi square statistic used in significance testing.
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openalex_W4293874313 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Olli S. Miettinen
Journal american journal of epidemiology
Year 1976
DOI
10.1093/oxfordjournals.aje.a112220
URL
https://doi.org/10.1093/oxfordjournals.aje.a112220
Keywords Keywords not found

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