Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis

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ID: 294951
2010
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Abstract
To calculate robust quantitative estimates on the predictive value of central pressures and derived central haemodynamic indices for cardiovascular (CV) outcomes and all-cause mortality by meta-analysis of longitudinal studies. We meta-analysed 11 longitudinal studies that had employed measures of central haemodynamics and had followed 5648 subjects for a mean follow-up of 45 months. The age- and risk-factor-adjusted pooled relative risk (RR) of total CV events was 1.088 (95% CI 1.040–1.139) for a 10 mmHg increase of central systolic pressure, 1.137 (95% CI 1.063–1.215) for a 10 mmHg increase of central pulse pressure (PP), and 1.318 (95% CI 1.093–1.588) for a 10% absolute increase of central augmentation index (AIx). Furthermore, we found that a 10% increase of central AIx was associated with a RR of 1.384 (95% CI 1.192–1.606) for all-cause mortality. When compared with brachial PP, central PP was associated with marginally but not significantly higher RR of clinical events (P = 0.057). Central haemodynamic indexes are independent predictors of future CV events and all-cause mortality. Augmentation index predicts clinical events independently of peripheral pressures, while central PP has a marginally but not significantly (P = 0.057) better predictive ability when compared with peripheral PP.
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Authors C Vlachopoulos, Konstantinos Aznaouridis, Michael F. O’Rourke, Michel E. Safar, Katerina Baou, Christodoulos Stefanadis
Journal european heart journal
Year 2010
DOI
10.1093/eurheartj/ehq024
URL
https://academic.oup.com/eurheartj/article-pdf/31/15/1865/2026257/ehq024.pdf
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