Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
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ID: 294921
2013
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Abstract
Hyperglycemia and insulin resistance are key players in the development of atherosclerosis and its complications. A large body of evidence suggest that metabolic abnormalities cause overproduction of reactive oxygen species (ROS). In turn, ROS, via endothelial dysfunction and inflammation, play a major role in precipitating diabetic vascular disease. A better understanding of ROS-generating pathways may provide the basis to develop novel therapeutic strategies against vascular complications in this setting. Part I of this review will focus on the most current advances in the pathophysiological mechanisms of vascular disease: (i) emerging role of endothelium in obesity-induced insulin resistance; (ii) hyperglycemia-dependent microRNAs deregulation and impairment of vascular repair capacities; (iii) alterations of coagulation, platelet reactivity, and microparticle release; (iv) epigenetic-driven transcription of ROS-generating and proinflammatory genes. Taken together these novel insights point to the development of mechanism-based therapeutic strategies as a promising option to prevent cardiovascular complications in diabetes.
| Reference Key |
openalex_W2158106881
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|---|---|
| Authors | Francesco Paneni, Joshua A. Beckman, Mark A. Creager, Francesco Cosentino |
| Journal | european heart journal |
| Year | 2013 |
| DOI |
10.1093/eurheartj/eht149
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| URL | |
| Keywords | Keywords not found |
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