Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
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ID: 294500
2009
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Abstract
Abstract TAM and other myeloid-derived tumor infiltrating cells are reviewed as pivotal players in the tumor microenvironment; implications to anti-cancer therapy are described. The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels and proteolytic enzymes. TAM, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors.
| Reference Key |
openalex_W2136166312
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|---|---|
| Authors | Graziella Solinas, Giovanni Germano, Alberto Mantovani, Paola Allavena |
| Journal | journal of leukocyte biology |
| Year | 2009 |
| DOI |
10.1189/jlb.0609385
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| URL | |
| Keywords | Keywords not found |
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