Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*

Clicks: 3
ID: 292259
1995
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #175 of 220 articles by views in endocrine reviews

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 220 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82 individuals (80 cases collated from the literature and two cases of his own) who had a female phenotype despite the presence of bilateral testes (1). Since his initial description, studies of the endocrinology, pathophysiology, biochemistry, and molecular biology of the androgen insensitivity syndrome (AIS) have provided insights into the role of androgens in male sex differentiation, the mechanisms of androgen action, and aspects of the structure/function relationships of the androgen receptor. AIS is an archetypal example of a hormone resistance disorder. Androgens are secreted by the testes of these 46,XY individuals in normal or increased amounts; however, due to defective androgen receptor (AR1) function, there is loss of target organ response to the hormone, and the effects of androgens are reduced or absent. Clinical disorders of the AR are reported far more commonly than resistance disorders of other members of the steroid receptor family and, in fact, more mutations have been reported in the AR gene than in that of any other transcription factor (2). This is, in part, due to the fact that the AR is encoded by a single copy X-chromosomal gene (it is the only X-chromosomal steroid receptor gene).
Reference Key
openalex_W2144908726 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Charmian A. Quigley, Alessandra De Bellis, Keith B. Marschke, Mostafa K. El Awady, Elizabeth M. Wilson, F.S. French
Journal endocrine reviews
Year 1995
DOI
10.1210/edrv-16-3-271
URL
https://doi.org/10.1210/edrv-16-3-271
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.