Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

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ID: 292164
1996
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Abstract
THE existence of mechanisms that provide immunity to an infective agent was inferred from empirical observations obtained through the ingenuity and deductive capacity of early investigators. The first procedures for vaccinations and serotherapy resulted from these observations. The implementation of these procedures, probably the most important contribution of immunology to medical science, was, at first, based on a very rudimentary knowledge of the immune system. During the first half of the 20th century, this rather primitive knowledge coincided with evidence showing that the endocrine and nervous systems integrate and regulate different bodily functions. Therefore, based on some supportive data, it was considered that immune mechanisms may also be influenced by these systems. However, at the beginning of the second half of the 20th century, most efforts were directed at understanding the molecular and cellular basis of the immune response and the mechanisms of acquisition of immunological diversity and self-tolerance.
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openalex_W1998086688 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hugo O. Besedovsky, Adriana del Rey
Journal endocrine reviews
Year 1996
DOI
10.1210/edrv-17-1-64
URL
https://academic.oup.com/edrv/article-pdf/17/1/64/9075482/edrv0064.pdf
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