Discrete sequential boundaries for clinical trials

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ID: 291511
1983
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Abstract
Pocock (1977), O'Brien & Fleming (1979) and Slud & Wei (1982) have proposed different methods to construct discrete sequential boundaries for clinical trials. These methods require that the total number of decision times be specified in advance. In the present paper, we propose a more flexible way to construct discrete sequential boundaries. The method is based on the choice of a function, α*(t), which characterizes the rate at which the error level α is spent. The boundary at a decision time is determined by α*(t), and by past and current decision times, but does not depend on the future decision times or the total number of decision times.
Reference Key
openalex_W1990639292 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors K. K. Gordon Lan, David L. DeMets
Journal jurnal biometrika dan kependudukan
Year 1983
DOI
10.1093/biomet/70.3.659
URL
https://doi.org/10.1093/biomet/70.3.659
Keywords Keywords not found

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