Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
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ID: 291092
2010
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Abstract
Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and custom TALE-nuclease fusions direct DNA double-strand breaks to specific, targeted sites.
| Reference Key |
openalex_W2112006537
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|---|---|
| Authors | Michelle Christian, Tomáš Čermák, Erin Doyle, Clarice Schmidt, Feng Zhang, Aaron W. Hummel, Adam J. Bogdanove, Daniel F. Voytas |
| Journal | current genetics |
| Year | 2010 |
| DOI |
10.1534/genetics.110.120717
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| URL | |
| Keywords | Keywords not found |
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