The Case-Crossover Design: A Method for Studying Transient Effects on the Risk of Acute Events

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ID: 290677
1991
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Abstract
A case-control design involving only cases may be used when brief exposure causes a transient change in risk of a rare acute-onset disease. The design resembles a retrospective nonrandomized crossover study but differs in having only a sample of the base population-time. The average incidence rate ratio for a hypothesized effect period following the exposure is estimable using the Mantel-Haenszel estimator. The duration of the effect period is assumed to be that which maximizes the rate ratio estimate. Self-matching of cases eliminates the threat of control-selection bias and increases efficiency. Pilot data from a study of myocardial infarction onset illustrate the control of within-individual confounding due to temporal association of exposures.
Reference Key
openalex_W2136527705 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Malcolm Maclure
Journal american journal of epidemiology
Year 1991
DOI
10.1093/oxfordjournals.aje.a115853
URL
https://doi.org/10.1093/oxfordjournals.aje.a115853
Keywords Keywords not found

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