Sequential Treatment Assignment with Balancing for Prognostic Factors in the Controlled Clinical Trial

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ID: 290597
1975
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Abstract
In controlled clinical trials there are usually several prognostic factors known or thought to influence the patient's ability to respond to treatment. Therefore, the method of sequential treatment assignment needs to be designed so that treatment balance is simultaneously achieved across all such patients factor. Traditional methods of restricted randomization such as "permuted blocks within strata" prove inadequate once the number of strata, or combinations of factor levels, approaches the sample size. A new general procedure for treatment assignment is described which concentrates on minimizing imbalance in the distributions of treatment numbers within the levels of each individual prognostic factor. The improved treatment balance obtained by this approach is explored using simulation for a simple model of a clinical trial. Further discussion centers on the selection, predictability and practicability of such a procedure.
Reference Key
openalex_W2000366267 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Stuart Pocock, Richard Simon
Journal biometrics
Year 1975
DOI
10.2307/2529712
URL
https://doi.org/10.2307/2529712
Keywords Keywords not found

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