The thrifty phenotype hypothesis

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ID: 290288
2001
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Abstract
The thrifty phenotype hypothesis proposes that the epidemiological associations between poor fetal and infant growth and the subsequent development of type 2 diabetes and the metabolic syndrome result from the effects of poor nutrition in early life, which produces permanent changes in glucose-insulin metabolism. These changes include reduced capacity for insulin secretion and insulin resistance which, combined with effects of obesity, ageing and physical inactivity, are the most important factors in determining type 2 diabetes. Since the hypothesis was proposed, many studies world-wide have confirmed the initial epidemiological evidence, although the strength of the relationships has varied from one study to another. The relationship with insulin resistance is clear at all ages studied. Less clear is the relationship with insulin secretion. The relative contribution of genes and environment to these relationships remains a matter of debate. The contributions of maternal hyperglycaemia and the trajectory of postnatal growth need to be clarified.
Reference Key
openalex_W2219578023 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C. N. Hales, David J. Barker
Journal british medical bulletin
Year 2001
DOI
10.1093/bmb/60.1.5
URL
https://academic.oup.com/bmb/article-pdf/60/1/5/25151505/5.pdf
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